Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages
Open Access
- 6 January 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 217 (4), 548-559
- https://doi.org/10.1093/infdis/jix509
Abstract
Two influenza B virus lineages, B/Victoria and B/Yamagata, cocirculate in the human population. While the lineages are serologically distinct, cross-reactive responses to both lineages have been detected. Viral interference describes the situation whereby infection with one virus limits infection and replication of a second virus. We investigated the potential for viral interference between the influenza B virus lineages. Ferrets were infected and then challenged 3, 10, or 28 days later with pairs of influenza B/Victoria and B/Yamagata viruses. Viral interference occurred at challenge intervals of 3 and 10 days and occasionally at 28 days. At the longer interval, shedding of challenge virus was reduced, and this correlated with cross-reactive interferon γ responses from lymph nodes from virus-infected animals. Viruses from both lineages could prevent or significantly limit subsequent infection with a virus from the other lineage. Coinfections were rare, indicating the potential for reassortment between lineages is limited. These data suggest that innate and cross-reactive immunity mediate viral interference and that this may contribute to the dominance of a specific influenza B virus lineage in any given influenza season. Furthermore, infection with one influenza B virus lineage may be beneficial in protecting against subsequent infection with either influenza B virus lineage.Keywords
Funding Information
- National Institutes of Health (HHSN272201400006C)
This publication has 43 references indexed in Scilit:
- Antigenic Drift of the Pandemic 2009 A(H1N1) Influenza Virus in a Ferret ModelPLoS Pathogens, 2013
- Human Monoclonal Antibodies Broadly Neutralizing against Influenza B VirusPLoS Pathogens, 2013
- The Coming Era of Quadrivalent Human Influenza VaccinesDrugs, 2012
- Respiratory viral infections during the 2009–2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infectionsEuropean Journal of Clinical Microbiology & Infectious Diseases, 2012
- Increased Risk of Noninfluenza Respiratory Virus Infections Associated With Receipt of Inactivated Influenza VaccineClinical Infectious Diseases, 2012
- Characterization of glycan binding specificities of influenza B viruses with correlation with hemagglutinin genotypes and clinical featuresJournal of Medical Virology, 2012
- The rationale for quadrivalent influenza vaccinesHuman Vaccines & Immunotherapeutics, 2012
- Vaccination against Seasonal Influenza A/H3N2 Virus Reduces the Induction of Heterosubtypic Immunity against Influenza A/H5N1 Virus Infection in FerretsJournal of Virology, 2011
- MDCK-SIAT1 Cells Show Improved Isolation Rates for Recent Human Influenza Viruses Compared to Conventional MDCK CellsJournal of Clinical Microbiology, 2008
- Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983Virology, 1990