Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes
- 20 May 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 283 (1), 7-10
- https://doi.org/10.1016/0014-5793(91)80541-a
Abstract
The effects of glucagon and the glucagon-like peptide GLP-I(7–37) were compared in rat liver hepatocytes. Glucagon elevated cAMP, elevated intracellular free calcium ([Ca 2+ ] 1 ), activated phosphorylase and stimulated gluconeogenesis, whereas GLP-I(7–37) was without effect on any of these parameters. GLP-I(7–37) did not block any of the actions of glucagon. The glucagon analog, des His 1 [Glu 9 ] glucagon, amide, was a partial agonist in liver, but also was an effective antagonist of glucagon actions in liver but not those of GLP-I(7–37) in islet B cells. It was concluded that in the rat, GLP-I(7–37) is a potent insulin secretagogue [1] but is without effect on liver.This publication has 18 references indexed in Scilit:
- Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3?,5?-Monophosphate Formation*Endocrinology, 1990
- Comparison of the Effects of Various C-Terminal and NTerminal Fragment Peptides of Glucagon-Like Peptide-1 on Insulin and Glucagon Release from the Isolated Perfused Rat Pancreas*Endocrinology, 1989
- Comparison of the Effects of Glucagon-Like Peptide-1-( 1-3 7) and -(7-37) and Glucagon on Islet Hormone Release from Isolated Perfused Canine and Rat Pancreases*Endocrinology, 1989
- Glucagonlike Peptide I (7–37) Actions on Endocrine PancreasDiabetes, 1989
- Glucagon-like peptide-1 (7–36 amide): a potent glucagonostatic and insulinotropic hormoneDiabetes Research and Clinical Practice, 1988
- GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MANThe Lancet, 1987
- Glucagon‐like peptides activate hepatic gluconeogenesisFEBS Letters, 1987
- Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.Proceedings of the National Academy of Sciences of the United States of America, 1987
- Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.JCI Insight, 1987
- Truncated glucagon‐like peptide I, an insulin‐releasing hormone from the distal gutFEBS Letters, 1987