Glucagon‐like peptides activate hepatic gluconeogenesis
- 13 July 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 219 (1), 227-232
- https://doi.org/10.1016/0014-5793(87)81222-x
Abstract
Piscine (anglerfish, catfish, coho salmon) glucagon-like peptides (GLPs), applied at 3.5 nM, stimulate (1.1–1.9-fold) flux through gluconeogenesis above control levels in isolated trout and salmon hepatocytes. Human GLP-1 and GLP-2 also activate gluconeogenesis, but to a lesser degree than their piscine counterparts. Minor increases of substrate oxidation are noticed at times of peak gluconeogenic activation through GLPs. These hormones, which are derived from the same precursor peptide as glucagon are more potent activators of gluconeogenesis than glucagon when applied at equimolar concentrations, and do not appear to employ cAMP or cGMP as the intracellular messenger in hepatic tissue.Keywords
This publication has 22 references indexed in Scilit:
- Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.JCI Insight, 1987
- A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagonNature, 1987
- Biological activities of catfish glucagon and glucagon-like peptideBiochemical and Biophysical Research Communications, 1987
- Activation of two signal-transduction systems in hepatocytes by glucagonNature, 1986
- Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequenceFEBS Letters, 1986
- Mechanism of glucagon stimulation of fructose‐1,6‐bisphosphatase in rat hepatocytesFEBS Letters, 1986
- Characterization of glucagon receptors in Golgi fractions of rat liver: evidence for receptors that are uncoupled from adenylyl cyclaseBiochemistry, 1986
- Specific glucagon-related peptides isolated from anglerfish islets are metabolic cleavage products of (pre)proglucagon-IIPeptides, 1986
- Stimulation of estrogen receptor accumulation by estradiol in primary cultures of salmon hepatocytesFEBS Letters, 1986
- Human glucagon‐like peptides 1 and 2 activate rat brain adenylate cyclaseFEBS Letters, 1984