Clinical Trial of Lamivudine in Children with Chronic Hepatitis B
Open Access
- 30 May 2002
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (22), 1706-1713
- https://doi.org/10.1056/nejmoa012452
Abstract
Lamivudine therapy is effective for chronic hepatitis B infection in adults. We evaluated the efficacy and tolerability of lamivudine as a treatment for chronic infection with hepatitis B virus (HBV) in children.Keywords
This publication has 17 references indexed in Scilit:
- Extended lamivudine treatment in patients with chronic hepatitis B enhances hepatitis B e antigen seroconversion rates: Results after 3 years of therapyHepatology, 2001
- Impact of chronic hepatitis B and interferon‐α therapy on growth of childrenJournal of Viral Hepatitis, 2001
- Lamivudine and alpha interferon combination treatment of patients with chronic hepatitis B infection: a randomised trialGut, 2000
- Lamivudine as Initial Treatment for Chronic Hepatitis B in the United StatesNew England Journal of Medicine, 1999
- Interferon-α Treatment of Chronic Hepatitis B in Childhood: A Consensus Advice Based on Experience in European ChildrenJournal of Pediatric Gastroenterology and Nutrition, 1999
- Identification and characterization of mutations in hepatitis B virus resistant to lamivudineHepatology, 1998
- Interferon alfa therapy for chronic hepatitis B in children: A multinational randomized controlled trialGastroenterology, 1998
- Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defectiveHepatology, 1998
- A Randomized, Controlled Trial of Interferon Alfa-2b Alone and after Prednisone Withdrawal for the Treatment of Chronic Hepatitis BNew England Journal of Medicine, 1990
- Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisHepatology, 1981