C-Reactive Protein and Risk of First-Ever Ischemic and Hemorrhagic Stroke in a General Japanese Population
Open Access
- 1 January 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 37 (1), 27-32
- https://doi.org/10.1161/01.str.0000194958.88216.87
Abstract
Background and Purpose— The role of high-sensitivity C-reactive protein (hsCRP) in the development of stroke is not clearly understood. We investigated the relationship between serum hsCRP levels and stroke occurrence in a general Japanese population. Methods— We followed 2692 subjects ≥40 years of age for 12 years. The relative risks and 95% CIs for ischemic and hemorrhagic stroke occurrence were calculated according to the hsCRP quintiles. Results— During the follow-up, 129 first-ever ischemic and 59 hemorrhagic strokes occurred. In men, the age-adjusted incidence of ischemic stroke significantly increased with elevated serum hsCRP levels; the difference between the first and fifth quintiles was statistically significant (1.4 versus 6.6 per 1000 person-years; P =0.02). This association remained significant even after adjustment for other confounding factors, such as age, systolic blood pressure, ECG abnormalities, diabetes, body mass index, total cholesterol, high-density lipoprotein cholesterol, smoking habits, alcohol intake, and regular exercise (adjusted relative risks, 3.11; 95% CI, 1.04 to 9.32; P =0.04). However, such associations were not observed for ischemic stroke in women or in hemorrhagic stroke in either sex. Among male subjects who were both in the fifth hsCRP level and had hypertension, diabetes, obesity, hypercholesterolemia, or a smoking habit, the risk of ischemic stroke was extremely increased, even after adjustment for other risk factors. Conclusions— Our findings suggest that elevated serum hsCRP levels are an independent risk factor for future ischemic stroke in Japanese men and that the coexistence of a high hsCRP level with another risk factor extremely increases the risk of ischemic stroke.Keywords
This publication has 15 references indexed in Scilit:
- C-Reactive Protein, Carotid Intima-Media Thickness, and Incidence of Ischemic Stroke in the ElderlyCirculation, 2003
- C-Reactive Protein and the Future Risk of Thromboembolic Stroke in Healthy MenCell Metabolism, 2003
- C-reactive protein and myocardial infarctionJournal of Clinical Epidemiology, 2002
- The Protective Effects of Estrogen on the Cardiovascular SystemNew England Journal of Medicine, 1999
- Phylogenetic Perspectives in Innate ImmunityScience, 1999
- Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy MenNew England Journal of Medicine, 1997
- Production of C-reactive protein and risk of coronary events in stable and unstable anginaThe Lancet, 1997
- Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control StudyAmerican Journal of Epidemiology, 1996
- Prevalence of Type 2 (non-insulin-dependent) diabetes mellitus and impaired glucose tolerance in the Japanese general population: the Hisayama studyDiabetologia, 1993
- Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6Hepatology, 1990