Phylogenetic Perspectives in Innate Immunity
- 21 May 1999
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 284 (5418), 1313-1318
- https://doi.org/10.1126/science.284.5418.1313
Abstract
The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity inDrosophilaand mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.Keywords
This publication has 90 references indexed in Scilit:
- MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGESAnnual Review of Immunology, 1999
- Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)The Journal of Experimental Medicine, 1999
- MALARIA PARASITE DEVELOPMENT IN MOSQUITOESAnnual Review of Entomology, 1998
- Mannose-binding lectin: the pluripotent molecule of the innate immune systemImmunology Today, 1996
- Structure and Orientation of the Mammalian Antibacterial Peptide Cecropin P1 within Phospholipid MembranesJournal of Molecular Biology, 1996
- Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface FluidCell, 1996
- Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient MiceImmunity, 1996
- Dorsoventral pattern formation in Drosophila: signal transduction and nuclear targetingTrends in Genetics, 1991
- Molecular basis of polymorphisms of human complement component C3.The Journal of Experimental Medicine, 1990
- CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding ProteinScience, 1990