Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory EffectIn Vitro
Open Access
- 1 January 2011
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2011, 1-10
- https://doi.org/10.1155/2011/515647
Abstract
Pancreatic-amylase inhibitors offer an effective strategy to lower the levels of post prandial hyperglycemia via control of starch breakdown. Eleven Ayurvedic Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for-amylase inhibition, in order to assess and evaluate their inhibitory potential on pancreatic-amylase. Analysis of 91 extracts, showed that 10 exhibited strong Human Pancreatic Amylase (HPA) inhibitory potential. Of these, 6 extracts showed concentration dependent inhibition withvalues, namely, cold and hot water extracts fromFicus bengalensisbark (4.4 and 125 ),Syzygium cuminiseeds (42.1 and 4.1 ), isopropanol extracts ofCinnamomum verumleaves (1.0 ) andCurcuma longarhizome (0.16 ). The other 4 extracts exhibited concentration independent inhibition, namely, methanol extract ofBixa orellanaleaves (49 ), isopropanol extract fromMurraya koenigiileaves (127 ), acetone extracts fromC. longarhizome (7.4 ) andTribulus terrestrisseeds (511 ). Thus, the probable mechanism of action of the above fractions is due to their inhibitory action on HPA, thereby reducing the rate of starch hydrolysis leading to lowered glucose levels. Phytochemical analysis revealed the presence of alkaloids, proteins, tannins, cardiac glycosides, flavonoids, saponins and steroids as probable inhibitory compounds.
Keywords
Funding Information
- University Grants Commission
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