Uterine contractions in rodent models and humans

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.
Funding Information
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (F30 HD097925, R01 HD037831, R01 HD088097, R01 HD096737)
  • Corteva Agriscience
  • March of Dimes Foundation (#6‐FY18‐664)