The Electrical Activities of the Uterus During Pregnancy
- 1 February 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Reproductive Sciences
- Vol. 20 (2), 182-189
- https://doi.org/10.1177/1933719112446082
Abstract
In contrast to the current state of knowledge of cardiac and of gastrointestinal electrophysiology, our current knowledge of the physiology of the uterus during pregnancy is still very rudimentary. Despite seminal work performed in the past decades, there are still significant areas that we know little about. In this review, some of these areas are explored. For example, although many studies have tried to find the site of the uterus pacemaker, such a site has not yet been found and its mechanism and location remain, to date, a mystery. Similarly, there is much confusion as to the mechanism of propagation of the electrical impulse. Although the existence of gap junctions, connecting neighboring myometrial cells to each other, have been known since 1977, alternative or additional mechanisms are being suggested such as the potential existence of a network of interstitial cells, similar to the one that is functioning in the gut, or the involvement of stretch receptors to synchronize activity and contraction. In recent years, high-resolution studies have been introduced enabling detailed analysis of the location and spatial patterns of propagation. This work is being developed at the in-vitro level in isolated tissues, in the whole organ and in several animal species. Most recently, a surge in new technology enabling high fidelity and high resolution recording from the human uterus through the abdominal wall are being explored which could ultimately lead to new diagnostic tools and a clearer understanding of the physiology of pregnancies and (premature) labor.Keywords
This publication has 83 references indexed in Scilit:
- Electrohysterographic propagation velocity for preterm delivery predictionAmerican Journal of Obstetrics and Gynecology, 2011
- Towards a computational reconstruction of the electrodynamics of premature and full term human labourProgress in Biophysics and Molecular Biology, 2011
- Noninvasive uterine electromyography for prediction of preterm deliveryAmerican Journal of Obstetrics and Gynecology, 2011
- Use of uterine electromyography to diagnose term and preterm laborActa Obstetricia et Gynecologica Scandinavica, 2010
- Origin and propagation of human gastric slow-wave activity defined by high-resolution mappingAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2010
- Fetal Neurological Assessment Using Noninvasive MagnetoencephalographyClinics in Perinatology, 2009
- Extraction, quantification and characterization of uterine magnetomyographic activity—A proof of concept case studyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2009
- The Cardiac Physiome: perspectives for the futureExperimental Physiology, 2009
- Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterusBMC Pregnancy and Childbirth, 2007
- Resting membrane potentials of pacemaker and non pacemaker areas in rat uterusLife Sciences, 1981