Transglutaminase type 2 in the regulation of proteostasis
- 20 June 2018
- journal article
- review article
- Published by Walter de Gruyter GmbH in Biological Chemistry
- Vol. 400 (2), 125-140
- https://doi.org/10.1515/hsz-2018-0217
Abstract
The maintenance of protein homeostasis (proteostasis) is a fundamental aspect of cell physiology that is essential for the survival of organisms under a variety of environmental and/or intracellular stress conditions. Acute and/or persistent stress exceeding the capacity of the intracellular homeostatic systems results in protein aggregation and/or damaged organelles that leads to pathological cellular states often resulting in cell death. These events are continuously suppressed by a complex macromolecular machinery that uses different intracellular pathways to maintain the proteome integrity in the various subcellular compartments ensuring a healthy cellular life span. Recent findings have highlighted the role of the multifunctional enzyme type 2 transglutaminase (TG2) as a key player in the regulation of intracellular pathways, such as autophagy/mitophagy, exosomes formation and chaperones function, which form the basis of proteostasis regulation under conditions of cellular stress. Here, we review the role of TG2 in these stress response pathways and how its various enzymatic activities might contributes to the proteostasis control.Keywords
This publication has 123 references indexed in Scilit:
- BAG3: a multifaceted protein that regulates major cell pathwaysCell Death & Disease, 2011
- Chaperone-mediated autophagy: Molecular mechanisms and physiological relevanceSeminars in Cell & Developmental Biology, 2010
- Mitochondria Supply Membranes for Autophagosome Biogenesis during StarvationCell, 2010
- Molecular mechanism of multivesicular body biogenesis by ESCRT complexesNature, 2010
- mTOR regulation of autophagyFEBS Letters, 2010
- Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3The EMBO Journal, 2009
- Toward unraveling membrane biogenesis in mammalian autophagyCurrent Opinion in Cell Biology, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Eating Oneself and Uninvited Guests: Autophagy-Related Pathways in Cellular DefenseCell, 2005
- Exosomes: endosomal-derived vesicles shipping extracellular messagesCurrent Opinion in Cell Biology, 2004