mTOR regulation of autophagy
Top Cited Papers
Open Access
- 18 January 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (7), 1287-1295
- https://doi.org/10.1016/j.febslet.2010.01.017
Abstract
Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily‐conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status, growth factor and stress signals. Although TOR has been known as a key regulator of autophagy for more than a decade, the underlying regulatory mechanisms have not been clearly understood. This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the autophagy machinery.Keywords
Funding Information
- National Institutes of Health (DK072004)
- Minnesota Obesity Center (P30DK50456)
This publication has 97 references indexed in Scilit:
- Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat BodyDevelopmental Cell, 2004
- The LKB1 tumor suppressor negatively regulates mTOR signalingCancer Cell, 2004
- Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the CytoskeletonCurrent Biology, 2004
- Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndromeGenes & Development, 2004
- LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formationJournal of Cell Science, 2004
- Dictyostelium Macroautophagy Mutants Vary in the Severity of Their Developmental DefectsOnline Journal of Public Health Informatics, 2004
- TSC2 Mediates Cellular Energy Response to Control Cell Growth and SurvivalCell, 2003
- Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegansScience, 2003
- Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding PartnerOnline Journal of Public Health Informatics, 2003
- Chemical Genetic Analysis of Apg1 Reveals A Non-kinase Role in the Induction of AutophagyMolecular Biology of the Cell, 2003