Biomarkers of Cervical Dysplasia and Carcinoma
Open Access
- 29 October 2011
- journal article
- review article
- Published by Hindawi Limited in Journal of Oncology
- Vol. 2012, 1-9
- https://doi.org/10.1155/2012/507286
Abstract
Although cervical cytology screening has decreased the incidence of cervical cancer in industrialized countries, HPV-related cervical disease, including premalignant and malignant lesions, continues to represent a major burden on the health care system. Some of the problems include the potential for either under- or overtreatment of women due to decreased specificity of screening tests as well as significant interobserver variability in the diagnosis of cervical dysplastic lesions. Although not completely elucidated, the HPV-driven molecular mechanisms underlying the development of cervical lesions have provided a number of potential biomarkers for both diagnostic and prognostic use in the clinical management of these women.This publication has 95 references indexed in Scilit:
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