Hepcidin Regulation of Iron Transport
- 1 November 2008
- journal article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 138 (11), 2284-2288
- https://doi.org/10.3945/jn.108.096347
Abstract
The discovery of hepcidin as a key regulator of iron homeostasis has advanced our current knowledge of this field. Liver-derived hepcidin peptide is secreted in response to iron and inflammation and interacts with the iron export protein ferroportin. This review summarizes recent advances discussed at the Symposium. A particular focus is on molecular interactions between hepcidin and ferroportin, the regulation of hepcidin expression by iron and inflammation, and emerging methods to measure serum hepcidin in human populations.Keywords
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