The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth ofSalmonella enterica
- 1 May 2006
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (5), 3065-7
- https://doi.org/10.1128/iai.74.5.3065-3067.2006
Abstract
We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellularSalmonellagrowth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsiveSalmonellagenes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.Keywords
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