Radiation therapy for the management of patients with HTLV-1–associated adult T-cell leukemia/lymphoma
Open Access
- 30 August 2012
- journal article
- Published by American Society of Hematology in Blood
- Vol. 120 (9), 1816-1819
- https://doi.org/10.1182/blood-2012-01-401349
Abstract
Human T-cell leukemia virus type 1–associated adult T-cell leukemia/lymphoma (ATL) typically has survivals measured in months with chemotherapy. One prior published series (1983-1991) assessed local radiotherapy for ATL. Ten consecutive patients with pathologically confirmed ATL treated with radiotherapy were reviewed. Subtypes included acute (n = 7), smoldering (n = 2), and lymphomatous (n = 1). Patients received an average of 2.5 systemic therapy regimens before radiotherapy. Twenty lesions (cutaneous = 10, nodal = 8, extranodal = 2) were treated to a mean of 35.4 Gy/2-3 Gy (range, 12-60 Gy). At 9.0-month mean follow-up (range, 0.1-42.0 months), all lesions symptomatically and radiographically responded, with in-field complete responses in 40.0% (nodal 37.5% vs cutaneous 50.0%; P = .62). No patient experienced in-field progression. Nine patients developed new/progressive out-of-field disease. Median survival was 17.0 months (3-year survival, 30.0%). No Radiation Therapy Oncology Group acute grade ≥ 3 or any late toxicity was noted. This report is the first to use modern radiotherapy techniques and finds effective local control across ATL subtypes. Radiotherapy should be considered for symptomatic local progression of ATL.Keywords
This publication has 17 references indexed in Scilit:
- Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapyOncogene, 2010
- Adult T-cell leukemia/lymphoma in Taiwan: An analysis of 17 patients and review of the literatureAsia-Pacific Journal of Clinical Oncology, 2010
- Epidemiology, Treatment, and Prevention of Human T-Cell Leukemia Virus Type 1-Associated DiseasesClinical Microbiology Reviews, 2010
- A critical analysis of prognostic factors in North American patients with human T‐cell lymphotropic virus type‐1‐associated adult T‐cell leukemia/lymphomaCancer, 2010
- Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trialsBone Marrow Transplantation, 2010
- Human T Cell Leukemia Virus Reactivation with Progression of Adult T-Cell Leukemia-LymphomaPLOS ONE, 2009
- Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus MeetingJournal of Clinical Oncology, 2009
- International Peripheral T-Cell and Natural Killer/T-Cell Lymphoma Study: Pathology Findings and Clinical OutcomesJournal of Clinical Oncology, 2008
- Natural history of adult T-cell leukemia/lymphoma and approaches to therapyOncogene, 2005
- Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphomaBritish Journal of Haematology, 1991