Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials
- 19 April 2010
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 46 (1), 116-118
- https://doi.org/10.1038/bmt.2010.92
Abstract
We have previously conducted clinical trials of allogeneic hematopoietic SCT with reduced-intensity conditioning regimen (RIC) for adult T-cell leukemia/lymphoma (ATLL)-a disease caused by human T-lymphotropic virus type 1 (HTLV-1) infection and having a dismal prognosis. Long-term follow-up studies of these trials revealed that 10 of the 29 patients have survived for a median of 82 months (range, 54-100 months) after RIC, indicating a possible curability of the disease by RIC. However, we have also observed that the patterns of post-RIC changes in HTLV-1 proviral load over time among the 10 survivors were classified into three patterns. This is the first report to clarify the long-term outcomes after RIC for ATLL patients.Keywords
This publication has 10 references indexed in Scilit:
- A Retrospective Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Adult T Cell Leukemia/Lymphoma (ATL): Clinical Impact of Graft-versus-Leukemia/Lymphoma EffectTransplantation and Cellular Therapy, 2008
- Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-Intensity Conditioning for Adult T Cell Leukemia/Lymphoma: Impact of Antithymocyte Globulin on Clinical OutcomeTransplantation and Cellular Therapy, 2008
- Allogeneic Bone Marrow Transplantation from Unrelated Human T-Cell Leukemia Virus-I–negative Donors for Adult T-Cell Leukemia/Lymphoma: Retrospective Analysis of Data from the Japan Marrow Donor ProgramTransplantation and Cellular Therapy, 2007
- Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphomaBlood, 2005
- Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphomaLeukemia, 2005
- HTLV‐1 provirus load in peripheral blood lymphocytes of HTLV‐1 carriers is diminished by green tea drinkingCancer Science, 2004
- Allogeneic haematopoietic stem cell transplantation for the treatment of adult T‐cell leukaemia/lymphomaBritish Journal of Haematology, 2003
- Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantationBone Marrow Transplantation, 2001
- Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detectionBone Marrow Transplantation, 1999
- Diagnostic criteria and classification of clinical subtypes of adult T‐cell leukaemia‐lymphomaBritish Journal of Haematology, 1991