Mixed nerve action potentials in acquired demyelinating polyneuropathy
- 1 January 1995
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 18 (1), 85-92
- https://doi.org/10.1002/mus.880180112
Abstract
Uncertainty about motor and sensory contributions in abnormal nerves has limited the use of mixed nerve action potentials (MNAPs). We recorded MNAPs in 21 patients with an acquired demyelinating neuropathy, 18 age-matched control subjects, and 10 patients with an axonal polyneuropathy. Bipolar and unipolar recordings from median and ulnar nerves were made above the elbow after electrical stimulation of the nerves at the wrist. Antidromic digital sensory action potentials and motor conduction velocity were also recorded for both nerves. In 19 median and 12 ulnar nerves from demyelinating polyneuropathy patients, compared with control subjects, MNAP amplitudes were significantly reduced (mean, 6 μV vs. 31 μV), MNAP velocities were mildly reduced (mean, 50 m/s vs. 62 m/s), motor conduction velocities were significantly reduced (mean, 33 m/s vs. 57 m/s), and MNAPs were significantly dispersed, with markedly prolonged rise times (mean, 2.0 ms vs. 1.0 ms). Compared with the axonal polyneuropathy group, MNAP amplitudes from the median nerve were similarly reduced (mean, 8 μV vs. 9 μV), MNAP velocities were only slightly slower (mean, 52 m/s vs. 58 m/s), but the rise times were significantly prolonged (mean, 2.0 ms vs. 1.2 ms). We conclude that, in acquired demyelinating neuropathies, the onset and, in some cases, the whole MNAP is from afferent fibers, which can be abnormally dispersed, and that, over the same segment, MNAP velocity is less affected than motor conduction velocity. 1995.© 1995 John Wiley &Sons, Inc.This publication has 17 references indexed in Scilit:
- Patterns of sensory nerve conduction abnormalities in demyelinating and axonal peripheral nerve disordersMuscle & Nerve, 1993
- Uni- and bipolar surface recording of human nerve responsesMuscle & Nerve, 1991
- The electrodiagnostic findings in polyneuropathies associated with IgM monoclonal gammopathiesMuscle & Nerve, 1990
- Effect of desynchronized inputs on compound sensory and muscle action potentialsMuscle & Nerve, 1988
- The optimal recording electrode configuration for compound sensory action potentials.Journal of Neurology, Neurosurgery & Psychiatry, 1988
- Chronic inflammatory demyelinating polyneuropathy of infancy: A corticosteroid‐responsive disorderAnnals of Neurology, 1986
- CHRONIC DEMYELINATING NEUROPATHY ASSOCIATED WITH BENIGN IGM PARAPROTEINAEMIABrain, 1983
- The physiological basis for symptoms in Guillain-Barré syndromeAnnals of Neurology, 1981
- A study of normal nerve action potentials using an averaging technique (barrier grid storage tube)Journal of Neurology, Neurosurgery & Psychiatry, 1965
- THE RECORDING OF NERVE ACTION POTENTIALS THROUGH SKIN IN MANJournal of Neurology, Neurosurgery & Psychiatry, 1949