The electrodiagnostic findings in polyneuropathies associated with IgM monoclonal gammopathies
- 1 December 1990
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 13 (12), 1113-1117
- https://doi.org/10.1002/mus.880131205
Abstract
Electrodiagnostic studies were analyzed in patients with neuropathy associated with IgM monoclonal proteins, 7 with anti-myelin associated glycoprotein reactivity (MAG) and 7 nonreactive to MAG. The findings were distinctly different in the two groups. The electrodiagnostic studies of all the MAG-reactive patients had demyelinating features with slowing of conduction and prolonged distal latencies while only one of the MAG-nonreactive patients had a demyelinating pattern. In fact, the MAG-nonreactive patients were a heterogeneous group, both electrodiagnostically and clinically. This study supports the concept that MAG-reactive polyneuropathy is demyelinating in type, and is caused by the activity of the IgM M-protein directed at an antigen in the myelin sheath.This publication has 10 references indexed in Scilit:
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