Preoperative peritonsillar lornoxicam infiltration is not superior to intravenous lornoxicam for pain relief following tonsillectomy in adults
- 1 September 2010
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Anaesthesiology
- Vol. 27 (9), 807-811
- https://doi.org/10.1097/eja.0b013e32833c3101
Abstract
Nonsteroidal anti-inflammatory drugs have peripheral analgesic effects. We compared the efficacy of peritonsillar infiltration versus intravenous (i.v.) lornoxicam on pain relief after tonsillectomy in adults. Sixty adult patients scheduled for tonsillectomy were randomly assigned into three groups in a double-blind placebo-controlled study. In the control group, the patients received i.v. and peritonsillar saline infiltration; in the infiltration group, they received i.v. isotonic saline and peritonsillar lornoxicam infiltration, whereas in the i.v. group they received i.v. lornoxicam and peritonsillar saline infiltration. Pain verbal analogue scale at rest and on swallowing, the time to the first postoperative analgesic request, the total postoperative analgesic consumption during the first 24 h, intraoperative blood loss and postoperative bleeding were evaluated. Preoperative lornoxicam administration resulted in a significant reduction in pain scores postoperatively in the infiltration and i.v. groups with no significant difference between them. The time to first postoperative analgesic request was 143 +/- 138 min in the control group compared with 684 +/- 328 and 750 +/- 316 min in the i.v. and infiltration groups, respectively; P value is less than 0.05. Similarly a higher total paracetamol consumption (2632 +/- 1065 mg) during the first postoperative day was recorded in the control group than in both the lornoxicam groups (1300 +/- 733 and 1600 +/- 754 mg), with no significant differences between the i.v. and infiltration groups. Comparable intraoperative blood losses with no posttonsillectomy bleeding were recorded in the three study groups. Peritonsillar infiltration or i.v. lornoxicam enhanced postoperative analgesia after tonsillectomy in adults. However, the analgesic efficacy of locally applied lornoxicam is not superior to the i.v. administration.Keywords
This publication has 26 references indexed in Scilit:
- The preemptive analgesic effect of lornoxicam in patients undergoing major abdominal surgery: A randomised controlled studyInternational Journal of Surgery, 2008
- Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyroneJournal of Clinical Anesthesia, 2008
- Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplastyEuropean Journal of Anaesthesiology, 2008
- The analgesic efficacy of preoperative versus postoperative lornoxicam in varicocele repairJournal of Clinical Anesthesia, 2007
- Analgesic effects of lornoxicam after total abdominal hysterectomyJournal of Opioid Management, 2007
- L’analgésie postopérative ne diffère pas après l’administration locale ou intraveineuse de méloxicam pour une herniorraphie inguinaleCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 2001
- A Comparison of Patient-Controlled Analgesia with Lornoxicam Versus Morphine in Patients Undergoing Lumbar Disk SurgeryAnesthesia & Analgesia, 1998
- Comparison of Tenoxicam by Intramuscular Injection or Wound Infiltration for Analgesia After Inguinal HerniorrhaphyAnesthesia & Analgesia, 1996
- Comparison of i.m. and local infiltration of ketorolac with and without local anaestheticBritish Journal of Anaesthesia, 1995
- Peritonsillar infiltration with low-dose tenoxicam after tonsillectomyBritish Journal of Anaesthesia, 1995