Plasma magnesium and the risk of new-onset hyperuricaemia in hypertensive patients
- 26 March 2020
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 124 (2), 156-163
- https://doi.org/10.1017/s0007114520001099
Abstract
We aimed to evaluate the relationship of plasma Mg with the risk of new-onset hyperuricaemia and examine any possible effect modifiers in hypertensive patients. This is a post hoc analysis of the Uric acid (UA) Sub-study of the China Stroke Primary Prevention Trial (CSPPT). A total of 1685 participants were included in the present study. The main outcome was new-onset hyperuricaemia defined as a UA concentration ≥417 μmol/l in men or ≥357 μmol/l in women. The secondary outcome was a change in UA concentration defined as UA at the exit visit minus that at baseline. During a median follow-up duration of 4·3 years, new-onset hyperuricaemia occurred in 290 (17·2 %) participants. There was a significantly inverse relation of plasma Mg with the risk of new-onset hyperuricaemia (per sd increment; OR 0·85; 95 % CI 0·74, 0·99) and change in UA levels (per sd increment; β −3·96 μmol/l; 95 % CI −7·14, −0·79). Consistently, when plasma Mg was analysed as tertiles, a significantly lower risk of new-onset hyperuricaemia (OR 0·67; 95 % CI 0·48, 0·95) and less increase in UA levels (β −8·35 μmol/l; 95 % CI −16·12, −0·58) were found among participants in tertile 3 (≥885·5 μmol/l) compared with those in tertile 1 (<818·9 μmol/l). Similar trends were found in males and females. Higher plasma Mg levels were associated with a decreased risk of new-onset hyperuricaemia in hypertensive adults.Keywords
This publication has 31 references indexed in Scilit:
- Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium StudiesJournal of Nutrition, 2013
- Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based studyAnnals Of The Rheumatic Diseases, 2012
- High plasma uric acid concentration: causes and consequencesDiabetology & Metabolic Syndrome, 2012
- Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus StudyPLOS ONE, 2011
- Prevalence of hyperuricemia in Bangkok populationClinical Rheumatology, 2011
- Plasma and dietary magnesium and risk of sudden cardiac death in womenThe American Journal of Clinical Nutrition, 2011
- Gout. Epidemiology of goutArthritis Research & Therapy, 2010
- Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence of DiabetesDiabetes Care, 2010
- Elevated Serum Uric Acid is an Independent Predictor for Cardiovascular Events in Patients With Severe Coronary Artery Stenosis Subanalysis of the Japanese Coronary Artery Disease (JCAD) StudyCirculation Journal, 2009
- Uric Acid and Cardiovascular RiskThe New England Journal of Medicine, 2008