Uric Acid and Cardiovascular Risk
Top Cited Papers
- 23 October 2008
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 359 (17), 1811-1821
- https://doi.org/10.1056/nejmra0800885
Abstract
This review summarizes relevant studies concerning uric acid and possible links to hypertension, renal disease, and cardiovascular disease. Whether uric acid is an independent risk factor for such diseases is still a point of debate. Current evidence is presented.Keywords
This publication has 125 references indexed in Scilit:
- Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential HypertensionJAMA, 2008
- Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin–angiotensin systemJournal of Hypertension, 2008
- Lowering serum urate does not improve endothelial function in patients with type 2 diabetesDiabetologia, 2007
- Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunctionThe Journal of Experimental Medicine, 2007
- Association between serum uric acid and prehypertension among US adultsJournal of Hypertension, 2007
- Xanthine Oxidoreductase Is a Regulator of Adipogenesis and PPARγ ActivityCell Metabolism, 2007
- The association between serum uric acid level and long-term incidence of hypertension: population-based cohort studyJournal of Human Hypertension, 2006
- Serum Uric Acid and Coronary Heart Disease in 9,458 Incident Cases and 155,084 Controls: Prospective Study and Meta-AnalysisPLoS Medicine, 2005
- Molecular identification of a danger signal that alerts the immune system to dying cellsNature, 2003
- Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proceedings of the National Academy of Sciences of the United States of America, 1981