The TIM gene family: emerging roles in immunity and disease
- 1 June 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 3 (6), 454-462
- https://doi.org/10.1038/nri1111
Abstract
The search for cell-surface markers that can distinguish T helper 1 (T(H)1) cells from T(H)2 cells has led to the identification of a new gene family, encoding the T-cell immunoglobulin mucin (TIM) proteins, some of which are differentially expressed by T(H)1 and T(H)2 cells. The role of the TIM-family proteins in immune regulation is just beginning to emerge. Here, we describe the various TIM-family members in mice and humans, and discuss the genetic and functional evidence for their role in regulating autoimmune and allergic diseases.Keywords
This publication has 45 references indexed in Scilit:
- Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese populationGenes & Immunity, 2003
- Association of the ADAM33 gene with asthma and bronchial hyperresponsivenessNature, 2002
- Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune diseaseNature, 2002
- Functional diversity of helper T lymphocytesNature, 1996
- Lymphocyte Homing and HomeostasisScience, 1996
- Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for AtopyNew England Journal of Medicine, 1995
- B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapyCell, 1995
- Regulation of Immunity to Parasites by T Cells and T Cell-Derived CytokinesAnnual Review of Immunology, 1992
- TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional PropertiesAnnual Review of Immunology, 1989
- Susceptibility of BALB/c mice carrying various DBA/2 genes to development of Friend murine leukemia virus-induced erythroleukemia.The Journal of Experimental Medicine, 1985