Functional diversity of helper T lymphocytes
- 31 October 1996
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 383 (6603), 787-793
- https://doi.org/10.1038/383787a0
Abstract
The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.This publication has 93 references indexed in Scilit:
- IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune diseaseImmunology Today, 1996
- IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell ResponsesImmunity, 1996
- Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseasesImmunology Today, 1995
- Th1 and Th2 subsets: paradigms lost?Immunology Today, 1995
- Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.The Journal of Experimental Medicine, 1995
- A TH1→TH2 switch is a critical step in the etiology of HIV infectionImmunology Today, 1993
- Disruption of the murine IL-4 gene blocks Th2 cytokine responsesNature, 1993
- Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic AsthmaThe New England Journal of Medicine, 1992
- Defining Protective Responses to Pathogens: Cytokine Profiles in Leprosy LesionsScience, 1991
- A functional dichotomy in CD4+ T lymphocytesImmunology Today, 1988