Chapter 11: Genome-Wide Association Studies
Top Cited Papers
Open Access
- 27 December 2012
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLoS Computational Biology
- Vol. 8 (12), e1002822
- https://doi.org/10.1371/journal.pcbi.1002822
Abstract
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.Keywords
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