Mechanisms of Vascular Aging: New Perspectives
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- 24 June 2010
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
- Vol. 65 (10), 1028-1041
- https://doi.org/10.1093/gerona/glq113
Abstract
This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and development of vascular disease in the elderly patients; and provides a landscape of molecular mechanisms involved in cellular oxidative stress resistance, which could be targeted for the prevention or amelioration of unsuccessful vascular aging. Practical interventions for prevention of age-associated vascular dysfunction and disease in old age are considered here based on emerging knowledge of the effects of anti-inflammatory treatments, regular exercise, dietary interventions, and caloric restriction mimetics.Keywords
This publication has 148 references indexed in Scilit:
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1Mechanisms of Ageing and Development, 2009
- Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Is Associated With Increased Aortic Pulse Wave Velocity in AdultsAmerican Journal of Hypertension, 2009
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life SpanCell Metabolism, 2008
- Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegansCell, 2008
- Single dose treatment with PARP-inhibitor INO-1001 improves aging-associated cardiac and vascular dysfunctionExperimental Gerontology, 2007
- Resveratrol improves health and survival of mice on a high-calorie dietNature, 2006
- Role of adiponectin in human skeletal muscle bioenergeticsCell Metabolism, 2006
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansNature, 2004
- Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysisThe Lancet, 2004
- Oxygen sensitivity severely limits the replicative lifespan of murine fibroblastsNature, 2003