Stromal-Derived Factor-1α Correlates With Circulating Endothelial Progenitor Cells and With Acute Lesion Volume in Stroke Patients
- 1 March 2011
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 42 (3), 618-625
- https://doi.org/10.1161/strokeaha.110.596007
Abstract
Background and Purpose— Endothelial progenitor cells (EPC) are important participants of neovascularization and are mobilized through signaling with stromal-derived factor (SDF-1α), vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor, and stem cell factor. The association between EPC levels and these growth factors (GF) in acute stroke has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and stroke severity in acute stroke patients. Methods— Seventeen patients were selected from 175 patients with imaging-confirmed acute ischemic stroke. EPC were quantified using CD34, CD133, and VEGF-R2 markers. Plasma VEGF, SDF-1α, granulocyte colony-stimulating factor, and stem cell factor were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the stroke onset. Results— Levels of SDF-1α strongly (r=0.6) correlated with the numbers of EPC subsets CD133+VEFG-R2+ (P+VEGF-R2+ (P+CD133+VEGF-R2+ (Pr=0.5) correlated with CD133+VEGF-R2+ (Pr=−0.49) correlated with baseline diffusion-weighted imaging lesion volumes (PPP<0.03) compared to day 1 (64 pg/mL). Conclusions— These results indicate that SDF-1α and stem cell factor correlate with an increase in EPC early in ischemic stroke patients.This publication has 50 references indexed in Scilit:
- Endothelial progenitor cells correlate with lesion volume and growth in acute strokeNeurology, 2010
- Circulating endothelial progenitor cells are not affected by acute systemic inflammationAmerican Journal of Physiology-Heart and Circulatory Physiology, 2010
- Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: Implications for increased cardiovascular riskAtherosclerosis, 2010
- CD133 Identifies a Human Bone Marrow Stem/Progenitor Cell Sub-population With a Repertoire of Secreted Factors That Protect Against StrokeMolecular Therapy, 2009
- Clinical Evidence That Very Small Embryonic-Like Stem Cells Are Mobilized Into Peripheral Blood in Patients After StrokeStroke, 2009
- Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cellsEuropean Heart Journal, 2008
- The combination of granulocyte colony-stimulating factor and stem cell factor significantly increases the number of bone marrow–derived endothelial cells in brains of mice following cerebral ischemiaBlood, 2008
- G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanismBlood, 2006
- Role of the α‐chemokine stromal cell‐derived factor (SDF‐1) in the developing and mature central nervous systemGlia, 2003
- Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic StrokeStroke, 2000