Serial Measurement of Vascular Endothelial Growth Factor and Transforming Growth Factor-β1 in Serum of Patients With Acute Ischemic Stroke
Open Access
- 1 August 2000
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 31 (8), 1863-1870
- https://doi.org/10.1161/01.str.31.8.1863
Abstract
Background and Purpose —Both vascular endothelial growth factor (VEGF) and transforming growth factor-β1 (TGF-β1) are expressed in higher than normal concentrations in the penumbra of patients after ischemic stroke. Because both cytokines are central to the processes of angiogenesis, tissue inflammation, and fibrosis, we performed serial measurements of these cytokines in patients with cerebral infarction and determined their relationship to stroke etiology and volume. Methods —We serially (at days 0, 1, 3, 7, and 14) measured the serum levels of VEGF and active TGF-β1 in 29 patients with acute ischemic stroke. Age-matched healthy subjects (n=26) were used as controls. Results —Expression of VEGF was significantly increased in the majority of patients after acute stroke at each of the time points compared with normal controls. Highest expression occurred at day 7 (588±121 pg/mL; P =0.005), and it remained significantly elevated at 14 days after stroke. Expression of VEGF correlated with infarct volume, clinical disability (Scandinavian Stroke Scale), and peripheral leukocytosis and was significantly higher in patients with atherothrombotic large-vessel disease and ischemic heart disease ( P P Conclusions —VEGF but not TGF-β1 showed a dramatic increase in serum of stroke patients. Correlation between stroke severity and VEGF concentration suggests it could be involved in the subsequent repair processes resulting in partial recovery after stroke. Correlation between VEGF expression and peripheral leukocytosis suggests that these changes may also reflect the immunologic status of the patient. VEGF may play an important role in the pathophysiology of acute ischemic stroke and could be of value in future treatment strategies.This publication has 27 references indexed in Scilit:
- TGF-β Is Elevated in the CSF of Patients with Severe Traumatic Brain Injuries and Parallels Blood-Brain Barrier FunctionJournal of Neurotrauma, 1999
- Inducible Nitric Oxide Production and Expression of Transforming Growth Factor-β1 in Serum and CSF after Cerebral Ischaemic Stroke in ManNitric Oxide, 1998
- Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-?Glia, 1998
- Angiogenesis and strokeDrug News & Perspectives, 1998
- Neuroprotective Signal Transduction: Relevance to StrokeNeuroscience & Biobehavioral Reviews, 1997
- Transforming growth factor‐β: The breaking open of a black boxBioEssays, 1997
- Vascular permeability factor in brain metastases: correlation with vasogenic brain edema and tumor angiogenesisJournal of Neurosurgery, 1994
- TGF‐βS and TGF‐β type II receptor in human epidermis: Differential expression in acute and chronic skin woundsThe Journal of Pathology, 1993
- Prognostic value of blood vessel density in ischaemic strokeThe Lancet, 1993
- Isoform‐Specific Effects of Transforming Growth Factors‐β on Degeneration of Primary Neuronal Cultures Induced by Cytotoxic Hypoxia or GlutamateJournal of Neurochemistry, 1993