Molecular cloning and characterization of the rat NMDA receptor
- 7 November 1991
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 354 (6348), 31-37
- https://doi.org/10.1038/354031a0
Abstract
A complementary DNA encoding the rat NMDA receptor has been cloned and characterized. The single protein encoded by the cDNA forms a receptor-channel complex that has electrophysiological and pharmacological properties characteristic of the NMDA receptor. This protein has a significant sequence similarity to the AMPA/kainate receptors and contains four putative transmembrane segments following a large extracellular domain. The NMDA receptor messenger RNA is expressed in neuronal cells throughout the brain regions, particularly in the hippocampus, cerebral cortex and cerebellum.Keywords
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