Cloning by functional expression of a member of the glutamate receptor family
- 1 December 1989
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 342 (6250), 643-648
- https://doi.org/10.1038/342643a0
Abstract
We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.Keywords
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