SARS-CoV-2 seropositivity after infection and antibody response to mRNA-based vaccination
Preprint
- 19 February 2021
- preprint
- Published by Cold Spring Harbor Laboratory
Abstract
The effect of SARS-CoV-2 infection on response to mRNA-based SARS-CoV-2 vaccines is not well-described. We assessed longitudinal SARS-CoV-2-specific antibody responses pre- and post-vaccination among individuals with and without prior infection. The antibody response to the first vaccine dose was almost two-fold higher in individuals who were seropositive before vaccination compared to those who were seronegative, suggesting that prior infection primes the immune response to the first dose of mRNA-based vaccine.Keywords
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