SARS-CoV-2 Infection in Health Care Personnel and Their Household Contacts at a Tertiary Academic Medical Center: Protocol for a Longitudinal Cohort Study (Preprint)
Preprint
- 17 November 2020
- preprint
- Published by JMIR Publications Inc.
Abstract
BACKGROUND Health care personnel (HCP) are at high risk for exposure to the SARS-CoV-2 virus. While personal protective equipment (PPE) may mitigate this risk, prospective data collection on its use and other risk factors for seroconversion in this population is needed. OBJECTIVE The primary objectives of this study are to (1) determine the incidence of, and risk factors for, SARS-CoV-2 infection among HCP at a tertiary care medical center and (2) actively monitor PPE use, interactions between study participants via electronic sensors, secondary cases in households, and participant mental health and well-being. METHODS To achieve these objectives, we designed a prospective, observational study of SARS-CoV-2 infection among HCP and their household contacts at an academic tertiary care medical center in North Carolina, USA. Enrolled HCP completed frequent surveys on symptoms and work activities and provided serum and nasal samples for SARS-CoV-2 testing every 2 weeks. Additionally, interactions between participants and their movement within the clinical environment were captured with a smartphone app and Bluetooth sensors. Finally, a subset of participants’ households was randomly selected every 2 weeks for further investigation, and enrolled households provided serum and nasal samples via at-home collection kits. RESULTS As of December 31, 2020, 211 HCP and 53 household participants have been enrolled. Recruitment and follow-up are ongoing and expected to continue through September 2021. CONCLUSIONS Much remains to be learned regarding the risk of SARS-CoV-2 infection among HCP and their household contacts. Through the use of a multifaceted prospective study design and a well-characterized cohort, we will collect critical information regarding SARS-CoV-2 transmission risks in the health care setting and its linkage to the community. INTERNATIONAL REGISTERED REPORT DERR1-10.2196/25410Keywords
Other Versions
- Published version: Version JMIR Research Protocols, 10, preprints
This publication has 27 references indexed in Scilit:
- Home collection of nasal swabs for detection of influenza in the Household Influenza Vaccine Evaluation StudyInfluenza and Other Respiratory Viruses, 2020
- Update Alert 3: Epidemiology of and Risk Factors for Coronavirus Infection in Health Care WorkersAnnals of Internal Medicine, 2020
- Asymptomatic SARS Coronavirus 2 infection: Invisible yet invincibleInternational Journal of Infectious Diseases, 2020
- Epidemiology of and Risk Factors for Coronavirus Infection in Health Care WorkersAnnals of Internal Medicine, 2020
- Investigation of nosocomial SARS-CoV-2 transmission from two patients to healthcare workers identifies close contact but not airborne transmission eventsInfection Control & Hospital Epidemiology, 2020
- Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)Science, 2020
- Am I Part of the Cure or Am I Part of the Disease? Keeping Coronavirus Out When a Doctor Comes HomeThe New England Journal of Medicine, 2020
- Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in ChinaJAMA, 2020
- Protecting health-care workers from subclinical coronavirus infectionThe Lancet Respiratory Medicine, 2020
- Self-Collected Mid-Turbinate Swabs for the Detection of Respiratory Viruses in Adults with Acute Respiratory IllnessesPLOS ONE, 2011