Inhibition of the metastatic spread and growth of B16‐BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
- 1 August 1994
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 58 (3), 460-464
- https://doi.org/10.1002/ijc.2910580326
Abstract
The synthetic matrix metalloproteinase inhibitor batimastat was tested for its ability to inhibit growth and metastatic spread of the B16-BL6 murine melanoma in syngeneic C57BL/6N mice. Intraperitoneal administration of batimastat resulted in a significant inhibition in the number of lung colonies produced by B16-BL6 cells injected i.v. The effect of batimastat on spontaneous metastases was examined in mice inoculated in the hind footpad with B16-BL6 melanoma. The primary tumor was removed surgically after 26-28 days. Batimastat was administered twice a day from day 14 to day 28 (pre-surgery) or from day 26 to day 44 (post-surgery). With both protocols, the median number of lung metastases was not significantly affected, but there was a significant reduction in the weight of the metastases. Finally, the effect of batimastat was examined on s.c. growth of B16-BL6 melanoma. Batimastat administered daily, starting at day of tumor transplantation, resulted in a significant growth delay, whereas treatment starting at advanced stage tumor only reduced tumor growth marginally. Our results indicate that a matrix metalloproteinase inhibitor can not only prevent the colonization of secondary organs by B16-BL6 cells but also limit the growth of solid tumors.Keywords
This publication has 16 references indexed in Scilit:
- Association Between Expression of Activated 72-Kilodalton Gelatinase and Tumor Spread in Non-Small-Cell Lung CarcinomaJNCI Journal of the National Cancer Institute, 1993
- Tumor Cell Invasion Inhibited by TIMP-2JNCI Journal of the National Cancer Institute, 1991
- A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomasNature, 1990
- Identification of an Inhibitor of Neovascularization from CartilageScience, 1990
- Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of MetalloproteinasesJNCI Journal of the National Cancer Institute, 1990
- Metalloproteinases and their inhibitors in matrix remodelingTrends in Genetics, 1990
- Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascadeCell, 1986
- Cancer metastasis is selective or random depending on the parent tumour populationNature, 1982
- Metastatic potential correlates with enzymatic degradation of basement membrane collagenNature, 1980