Identification of an Inhibitor of Neovascularization from Cartilage
- 15 June 1990
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 248 (4961), 1408-1410
- https://doi.org/10.1126/science.1694043
Abstract
Certain tissues such as cartilage are resistant to vascular invasion, yet no single tissue-derived molecule that can inhibit angiogenesis has been reported. A protein derived from cartilage was purified that inhibits angiogenesis in vivo and capillary endothelial cell proliferation and migration in vitro in three separate bioassays. This protein is also an inhibitor of mammalian collagenase. These findings may help elucidate the mechanisms by which neovascularization is controlled in both normal and pathological states.This publication has 25 references indexed in Scilit:
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