A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses
- 7 November 2016
- journal article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 18 (1), 96-103
- https://doi.org/10.1038/ni.3598
Abstract
Lymphocytes integrate multiple input signals to regulate the extent of their proliferative response. Hodgkin and colleagues demonstrate that the proto-oncoprotein Myc is a cell-intrinsic division timer.Keywords
This publication has 36 references indexed in Scilit:
- T-cell stimuli independently sum to regulate an inherited clonal division fateNature Communications, 2016
- Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansionScience, 2014
- Intracellular competition for fates in the immune systemTrends in Cell Biology, 2012
- The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte ActivationImmunity, 2011
- Quantitative Regulation of B Cell Division Destiny by Signal StrengthThe Journal of Immunology, 2008
- The mystery of intracellular developmental programmes and timersBiochemical Society Transactions, 2006
- Making MycPublished by Springer Science and Business Media LLC ,2006
- c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma CellsMolecular and Cellular Biology, 2000
- Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survivalProceedings of the National Academy of Sciences of the United States of America, 1999
- An Intrinsic Timer That Controls Cell-Cycle Withdrawal in Cultured Cardiac MyocytesDevelopmental Biology, 1999