Making Myc
- 1 January 2006
- book chapter
- review article
- Published by Springer Science and Business Media LLC
- Vol. 302, 1-32
- https://doi.org/10.1007/3-540-32952-8_1
Abstract
Myc regulates to some degree every major process in the cell. Proliferation, growth, differentiation, apoptosis, and metabolism are all under Myc control. In turn, these processes feed back to adjust the level of c-myc expression. Although Myc is regulated at every level from RNA synthesis to protein degradation, c-myc transcription is particularly responsive to multiple diverse physiological and pathological signals. These signals are delivered to the c-myc promoter by a wide variety of transcription factors and chromatin remodeling complexes. How these diverse and sometimes disparate signals are processed to manage the output of the c-myc promoter involves chromatin, recruitment of the transcription machinery, post-initiation transcriptional regulation, and mechanisms to provide dynamic feedback. Understanding these mechanisms promises to add new dimensions to models of transcriptional control and to reveal new strategies to manipulate Myc levels.Keywords
This publication has 104 references indexed in Scilit:
- Spatial proximity of translocation-prone gene loci in human lymphomasNature Genetics, 2003
- Loss of Protooncogene c-Myc Function Impedes G1 Phase Progression Both before and after the Restriction PointMolecular Biology of the Cell, 2003
- The solution structure and DNA-binding properties of the cold-shock domain of the human Y-box protein YB-1Journal of Molecular Biology, 2002
- Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated TranscriptionCell, 2000
- Major DNA replication initiation sites in thec-myc locus in human cellsJournal of Cellular Biochemistry, 2000
- DNA binding of USF is required for specific E-box dependent gene activation in vivoOncogene, 1999
- Reconstitution of the Transcription Factor TFIIH: Assignment of Functions for the Three Enzymatic Subunits, XPB, XPD, and cdk7Molecular Cell, 1999
- Cellular nucleic acid binding protein binds a conserved region of the 5′ UTR of Xenopus laevis ribosomal protein mRNAsJournal of Molecular Biology, 1997
- Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression DomainsPublished by Elsevier BV ,1997
- Energetics of the strand separation transition in superhelical DNAJournal of Molecular Biology, 1992