Elevated Uric Acid Increases the Risk for Kidney Disease
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- 1 December 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Society of Nephrology
- Vol. 19 (12), 2407-2413
- https://doi.org/10.1681/asn.2008010080
Abstract
Recent epidemiologic studies suggest that uric acid predicts the development of new-onset kidney disease, but it is unclear whether uric acid is an independent risk factor. In this study, data from 21,475 healthy volunteers who were followed prospectively for a median of 7 yr were analyzed to examine the association between uric acid level and incident kidney disease (estimated GFR [eGFR] 2). After adjustment for baseline eGFR, a slightly elevated uric acid level (7.0 to 8.9 mg/dl) was associated with a nearly doubled risk for incident kidney disease (odds ratio 1.74; 95% confidence interval 1.45 to 2.09), and an elevated uric acid (≥9.0 mg/dl) was associated with a tripled risk (odds ratio 3.12; 95% confidence interval 2.29 to 4.25). These increases in risk remained significant even after adjustment for baseline eGFR, gender, age, antihypertensive drugs, and components of the metabolic syndrome (waist circumference, HDL cholesterol, blood glucose, triglycerides, and BP). In a fully adjusted spline model, the risk for incident kidney disease increased roughly linearly with uric acid level to a level of approximately 6 to 7 mg/dl in women and 7 to 8 mg/dl in men; above these levels, the associated risk increased rapidly. In conclusion, elevated levels of uric acid independently increase the risk for new-onset kidney disease.Keywords
This publication has 45 references indexed in Scilit:
- Uric acid and the development of metabolic syndrome in women and menMetabolism, 2008
- Uric Acid and Incident Kidney Disease in the CommunityJournal of the American Society of Nephrology, 2008
- Prevalence of Chronic Kidney Disease in the United StatesJAMA, 2007
- The Effect of Mild Hyperuricemia on Urinary Transforming Growth Factor Beta and the Progression of Chronic Kidney DiseaseAmerican Journal of Nephrology, 2007
- Predictors of new-onset decline in kidney function in a general middle-european populationNephrology Dialysis Transplantation, 2007
- Unearthing uric acid: An ancient factor with recently found significance in renal and cardiovascular diseaseKidney International, 2006
- Uric Acid – A Uremic Toxin?Blood Purification, 2005
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005
- Relations of Serum Uric Acid to Longitudinal Blood Pressure Tracking and Hypertension IncidenceHypertension, 2005
- Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?Hypertension, 2003