Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Top Cited Papers
- 1 June 2003
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 41 (6), 1183-1190
- https://doi.org/10.1161/01.hyp.0000069700.62727.c5
Abstract
Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.Keywords
This publication has 80 references indexed in Scilit:
- Uric Acid Stimulates Monocyte Chemoattractant Protein-1 Production in Vascular Smooth Muscle Cells Via Mitogen-Activated Protein Kinase and Cyclooxygenase-2Hypertension, 2003
- Prognostic Significance of Renal Function in Elderly Patients with Isolated Systolic HypertensionJournal of the American Society of Nephrology, 2002
- Molecular identification of a renal urate–anion exchanger that regulates blood urate levelsNature, 2002
- Uric acid and serum antioxidant capacity: a reaction to atherosclerosis?Atherosclerosis, 2000
- Antioxidation mechanisms of uric acidJournal of the American Chemical Society, 1989
- Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham StudyAmerican Heart Journal, 1987
- Ethanol-Induced HyperuricemiaThe New England Journal of Medicine, 1982
- Serum uric acid: Its association with other risk factors and with mortality in coronary heart diseaseJournal of Chronic Diseases, 1976
- The influence of allopurinol on renal function in goutArthritis & Rheumatism, 1975
- The incidence of hypertension and associated factors: The Israel ischemic heart disease studyAmerican Heart Journal, 1972