A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids
Open Access
- 12 January 2012
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 134 (3), 1454-1457
- https://doi.org/10.1021/ja210496n
Abstract
Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to “translate” certain aspects of the organismal energy state into global zinc signals.This publication has 45 references indexed in Scilit:
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