The Essential Toxin: Impact of Zinc on Human Health
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Open Access
- 26 March 2010
- journal article
- review article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 7 (4), 1342-1365
- https://doi.org/10.3390/ijerph7041342
Abstract
Compared to several other metal ions with similar chemical properties, zinc is relatively harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a rare event. In addition to acute intoxication, long-term, high-dose zinc supplementation interferes with the uptake of copper. Hence, many of its toxic effects are in fact due to copper deficiency. While systemic homeostasis and efficient regulatory mechanisms on the cellular level generally prevent the uptake of cytotoxic doses of exogenous zinc, endogenous zinc plays a significant role in cytotoxic events in single cells. Here, zinc influences apoptosis by acting on several molecular regulators of programmed cell death, including caspases and proteins from the Bcl and Bax families. One organ where zinc is prominently involved in cell death is the brain, and cytotoxicity in consequence of ischemia or trauma involves the accumulation of free zinc. Rather than being a toxic metal ion, zinc is an essential trace element. Whereas intoxication by excessive exposure is rare, zinc deficiency is widespread and has a detrimental impact on growth, neuronal development, and immunity, and in severe cases its consequences are lethal. Zinc deficiency caused by malnutrition and foods with low bioavailability, aging, certain diseases, or deregulated homeostasis is a far more common risk to human health than intoxication.Keywords
This publication has 178 references indexed in Scilit:
- Gastroduodenal Corrosive Injury After Oral Zinc OxideAnnals of Emergency Medicine, 2006
- Zinc deficiency and its inherited disorders -a reviewGenes & Nutrition, 2006
- Zinc-induced anemia and neutropenia in an adolescentThe Journal of Pediatrics, 2000
- Zinc Suppresses Apoptosis of U937 Cells Induced by Hydrogen Peroxide through an Increase of the Bcl-2/Bax RatioBiochemical and Biophysical Research Communications, 1998
- Effects on wound healing of zinc oxide in a hydrocolloid dressingJournal of the American Academy of Dermatology, 1993
- Basic mechanisms of traumatic brain damageAnnals of Emergency Medicine, 1993
- Biochemical changes in copper deficiencyThe Journal of Nutritional Biochemistry, 1990
- Acrodermatitis enteropathicaJournal of Inherited Metabolic Disease, 1983
- Zinc deficiency and geophagiaThe Journal of Pediatrics, 1982
- Inhibitory Effect of High Dietary Zinc on Copper Absorption in RatsCHEMICAL & PHARMACEUTICAL BULLETIN, 1974