Impact of Weight on Immune Cell Counts among HIV-Infected Persons
Open Access
- 27 April 2011
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 18 (6), 940-946
- https://doi.org/10.1128/cvi.00020-11
Abstract
Prior studies have shown that weight may impact immune cell counts. However, few data exist about the relationship of weight and immune cell counts among HIV-infected patients. We examined documented HIV seroconverters (mean window, 15.7 months) in a prospective U.S. Military HIV Natural History Study (1 January 1986 to 20 January 2010). We estimated the association of the time-updated body mass index (BMI) category with changes in immune cell counts from HIV diagnosis across time (mean follow-up of 5.1 years) using multiply adjusted longitudinal linear mixed-effects models. Of 1,097 HIV seroconverters, 448 (41%) were overweight and 93 (8%) were obese at HIV diagnosis. Immune cell counts at HIV diagnosis did not significantly differ by BMI category. In the longitudinal models for those diagnosed before the advent of the highly active antiretroviral therapy (HAART) era, mean postdiagnosis decreases in the white cell count, total lymphocyte count, CD4 count, CD4 percentage, and CD4/CD8 ratio were less as the BMI category increased (all withPvalues of Pvalues of <0.05). Similar findings were also noted among underweight versus normal-weight patients. In conclusion, although BMI was not associated with immune cell levels at the time of HIV diagnosis, weight appears to affect immune cells counts over the course of infection. In the HAART era, being either underweight or obese was associated with smaller increases in several important immune cell levels, including the CD4/CD8 ratio.Keywords
This publication has 52 references indexed in Scilit:
- Association between H1N1 Infection Severity and Obesity—Adiponectin as a Potential Etiologic FactorThe Journal of Infectious Diseases, 2010
- Body mass index and risk of tuberculosis and deathAIDS, 2010
- Obesity among HIV-infected persons: impact of weight on CD4 cell countAIDS, 2010
- Obesity and Dyslipidemia in Behaviorally HIV‐Infected Young Women: Adolescent Trials Network Study 021Clinical Infectious Diseases, 2010
- Obesity and lymphocyte subsets in virologically suppressed HIV-infected patientsMetabolism, 2009
- Obesity among Patients with HIV: The Latest EpidemicAIDS Patient Care and STDs, 2008
- Obesity and immune cell counts in womenMetabolism, 2007
- Alterations in peripheral blood lymphocyte cytokine expression in obesityClinical and Experimental Immunology, 2006
- Reduced tetanus antibody titers in overweight childrenAutoimmunity, 2006
- T lymphopaenia in relation to body mass index and TNF‐α in human obesity: adequate weight reduction can be correctiveClinical Endocrinology, 2001