Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma
- 26 July 2018
- journal article
- research article
- Published by Elsevier BV in Cancer Cell
- Vol. 34 (2), 286-297.e10
- https://doi.org/10.1016/j.ccell.2018.06.014
Abstract
• BATF3 and IRF4 are master regulators of ATLL gene expression and proliferation • HBZ drives BATF3 expression by binding to a super-enhancer in the BATF3 locus • BET inhibitors collapse the transcriptional network directed by HBZ and BATF3/IRF4 • BET inhibitors are toxic for ATLL cells ex vivo and block ATLL xenograft growthKeywords
Funding Information
- NIH
- National Cancer Institute
- Center for Cancer Research
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