Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice
- 1 December 2012
- journal article
- Published by Elsevier BV in Life Sciences
- Vol. 91 (23-24), 1169-1176
- https://doi.org/10.1016/j.lfs.2011.12.022
Abstract
No abstract availableKeywords
Funding Information
- Alzheimer's Association (IIRG-09-132098)
- Ministry of Education, Culture, Sports, Science and Technology (17300114, 18023033, 20023026, 20023027, 21390271, 21500352)
- Ministry of Health, Labour and Welfare
This publication has 50 references indexed in Scilit:
- Hypercholesterolemia in rats impairs the cholinergic system and leads to memory deficitsMolecular and Cellular Neuroscience, 2010
- Effects of Synaptic Modulation on β-Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic MiceJournal of Neuroscience, 2010
- The effects of cholesterol on learning and memoryNeuroscience & Biobehavioral Reviews, 2010
- Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 MiceJournal of Neuroscience, 2010
- Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s diseaseActa Neuropathologica, 2010
- Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicityProceedings of the National Academy of Sciences of the United States of America, 2010
- Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptideProceedings of the National Academy of Sciences of the United States of America, 2009
- Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene ExpressionThe American Journal of Pathology, 2009
- Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ productionNeurobiology of Disease, 2007
- Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomersNeurobiology of Aging, 2007