Potentiated adherence of sickle erythrocytes to endothelium infected by virus.
Open Access
- 1 November 1987
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 80 (5), 1503-1506
- https://doi.org/10.1172/jci113233
Abstract
Systemic viral infection is a known precipitant of vasocclusive crisis in sickle patients, but the mechanism underlying this clinical observation is unknown. In the present studies, human umbilical vein endothelial cells were infected with Herpes simplex virus type 1 (HSV) to model systemic viral disease. The already abnormal adherence of sickle erythrocytes to control endothelium is enhanced 1.8 +/- 0.4-fold to HSV-infected endothelium (P less than 0.001). This component of potentiated adherence is eliminated by maneuvers that block Fc receptors, it is prevented by tunicamycin, and it is not seen using a mutant HSV that is unable to express the Fc receptor glycoprotein. Thus, the incremental adherence seen here occurs due to expression of Fc receptor activity on HSV-infected endothelium and the consequent recognition of abnormal amounts of IgG on sickle erythrocytes. We conclude that systemic viral infection potentially can induce a novel mechanism for enhancement of erythrocyte adherence to endothelium and that this may increase the likelihood of vasocclusion during viral infection.This publication has 20 references indexed in Scilit:
- Excessive binding of natural anti-alpha-galactosyl immunoglobin G to sickle erythrocytes may contribute to extravascular cell destruction.JCI Insight, 1986
- Adherence properties of sickle erythrocytes in dynamic flow systems.1985
- Virus Infection of Endothelial CellsThe Journal of Infectious Diseases, 1981
- Erythrocyte Adherence to Endothelium in Sickle-Cell AnemiaThe New England Journal of Medicine, 1980
- Abnormal Adherence of Sickle Erythrocytes to Cultured Vascular EndotheliumJCI Insight, 1980
- Interactions between vessel wall and perfused sickled erythrocytes: preliminary observations.1980
- Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures.1979
- Fc receptors induced by herpes simplex virus. I. Biologic and biochemical properties.1978
- Characteristics of the Fc Receptor Induced by Herpes Simplex VirusIntervirology, 1978
- Genetic and Biochemical Studies with HerpesvirusCold Spring Harbor Symposia on Quantitative Biology, 1974