A unique signature identifies a family of zinc‐dependent metallopeptidases
- 2 January 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 242 (2), 211-214
- https://doi.org/10.1016/0014-5793(89)80471-5
Abstract
The primary sequence motif HExxH has been found in many zinc-dependent endopeptidases. We show that a larger signature comprising this sequence is common to most of the known zinc-dependent endopeptidases, and that the presence of the signature can be indicative of membership in the family. A search of the protein sequence databases for entries containing the signature retrieved several unexpected potential zinc endopeptidases.Keywords
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