One-Pot Procedure for Diazo Transfer and Azide−Alkyne Cycloaddition: Triazole Linkages from Amines
Open Access
- 14 December 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 9 (1), 1-4
- https://doi.org/10.1021/ol0621506
Abstract
A one-pot reaction for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide−alkyne 1,3-dipolar cycloaddition (sometimes called click reaction) is reported. 1,4-Disubstituted 1,2,3-triazoles are obtained in excellent yields from a variety of readily available amines without the need for isolation of the azide intermediates. The reaction has a broad scope and is especially practical for the synthesis of multivalent structures because compounds substituted with multiple azides are potentially unstable.Keywords
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