The potential role of podoplanin in tumour invasion
Open Access
- 19 December 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 96 (1), 1-5
- https://doi.org/10.1038/sj.bjc.6603518
Abstract
Podoplanin is a small mucin-like transmembrane protein, widely expressed in various specialised cell types throughout the body. Here, we revisit the mechanism of podoplanin-mediated tumour invasion. We compare molecular pathways leading to single and collective cell invasion and discuss novel distinct concepts of tumour cell invasion.Keywords
This publication has 31 references indexed in Scilit:
- Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transitionJournal of Cell Science, 2006
- Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeletonCancer Cell, 2006
- Podoplanin: A Novel Diagnostic Immunohistochemical MarkerAdvances in Anatomic Pathology, 2006
- The diagnostic utility of immunohistochemistry in distinguishing between epithelioid mesotheliomas and squamous carcinomas of the lung: a comparative studyLaboratory Investigation, 2006
- L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancersThe Journal of cell biology, 2005
- Podoplanin as a marker for mesotheliomaPathology International, 2005
- Characterization of human PA2.26 antigen (T1α-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomasInternational Journal of Cancer, 2004
- Tumour-cell invasion and migration: diversity and escape mechanismsNature Reviews Cancer, 2003
- T1α, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birthDevelopmental Biology, 2003
- Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesNature, 1985