Cimethidine Pre‐Anesthetic
- 11 January 1983
- journal article
- research article
- Published by Wiley in Acta Obstetricia et Gynecologica Scandinavica
- Vol. 62 (2), 157-159
- https://doi.org/10.3109/00016348309155782
Abstract
Twenty patients undergoing cesarean section received cimethidine 400 mg intramuscularly as pre-anesthetic approximately 70 minutes prior to gastric aspiration. The average pH was 5.05, as against 2.97 in the control group (p less than 0.01). No significant reduction in the aspirated volumes was observed. In the cimethidine group the proportion of patients at risk of developing Mendelson's syndrome (pH less than 2.5 and volume greater than 25 ml) was significantly reduced, viz. 5% as against 42% in the control group (P = 0.014). No perinatal effects attributable to cimethidine was observed in the infants. Hence, cimethidine is a safe and useful pre-anesthetic for patients undergoing cesarean section, irrespective of indication and, consequently, much to be preferred to oral antacids.Keywords
This publication has 10 references indexed in Scilit:
- Safety of Cimetidine in Obstetric PatientsJournal of the Royal Society of Medicine, 1979
- Antacid Pulmonary Aspiration in the DogAnesthesiology, 1979
- Life-threatening arrhythmias and intravenous cimetidine.BMJ, 1979
- Histamine2Receptor Antagonism by Cimetidine and Sinus-Node FunctionThe New England Journal of Medicine, 1979
- Bioavailability of cimetidine in manGastroenterology, 1978
- Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.British Journal of Clinical Pharmacology, 1975
- Some effects of histamine in the depolarized rat uterusBritish Journal of Pharmacology, 1973
- Cardiorespiratory Studies in Critical IllnessArchives of Surgery, 1971
- THE PROPHYLACTIC USE OF ANTACIDS IN THE PREVENTION OF THE ACID-PULMONARY-ASPIRATION SYNDROME (MENDELSON'S SYNDROME)The Lancet, 1966
- The Aspiration of Stomach Contents into the Lungs During Obstetric AnesthesiaAmerican Journal of Obstetrics and Gynecology, 1946