Histamine2Receptor Antagonism by Cimetidine and Sinus-Node Function
- 13 September 1979
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 301 (11), 591-592
- https://doi.org/10.1056/nejm197909133011106
Abstract
SEVERE bradycardia has been reported with the use of cimetidine.1 2 3 Bradycardia could have been spurious, but it recurred on rechallenge.1 , 2 Data from animal studies4 , 5 and human right-atrial fibers6 indicate that histamine-enhanced automaticity is antagonized by histamine2 blockers. These observations suggest that histamine2-receptor antagonism by cimetidine could worsen sick-sinus syndrome or blunt the chronotropic response to gastrointestinal hemorrhage. Therefore, we assessed the effect of cimetidine on sinus-node function in patients undergoing electrophysiologic testing.MethodsTen unmedicated patients underwent atrial pacing by use of a quadripolar catheter positioned at the upper portion of the right atrium. Heart rate (average . . .This publication has 11 references indexed in Scilit:
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