Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts
- 1 December 2004
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 64 (23), 8492-8495
- https://doi.org/10.1158/0008-5472.can-04-1708
Abstract
The role of myofibroblasts in tissue repair and fibrosis is well documented, but the source of these myofibroblasts is unclear. There is evidence of a circulating population of fibrocytes that can home to areas of injury and contribute to myofibroblast populations. Previously, we have shown that the bone marrow is a source of myofibroblasts for many tissues including the gut, lung, and kidney and that this phenomenon is exacerbated by injury. We now show that the bone marrow can contribute to myofibroblast and fibroblast populations in tumor stroma in a mouse model of pancreatic insulinoma. Mice transgenic for the rat insulin promoter II gene linked to the large-T antigen of SV40 (RIPTag) develop solid β-cell tumors of the pancreas. Approximately 25% of myofibroblasts in these pancreatic tumors were donor-derived, and these were concentrated toward the edge of the tumor. Thus, the development of tumor stroma is at least in part a systemic response that may ultimately yield methods of targeting new therapy.Keywords
This publication has 18 references indexed in Scilit:
- Histological categorisation of fibrotic cancer stroma in advanced rectal cancerGut, 2004
- Multiple Organ Engraftment by Bone‐Marrow‐Derived Myofibroblasts and Fibroblasts in Bone‐Marrow‐Transplanted MiceThe International Journal of Cell Cloning, 2003
- The myofibroblast in wound healing and fibrocontractive diseasesThe Journal of Pathology, 2003
- Role of tissue stroma in cancer cell invasionThe Journal of Pathology, 2003
- There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesionsJournal of Clinical Pathology, 2003
- Cell fusion is the principal source of bone-marrow-derived hepatocytesNature, 2003
- Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stromaJournal of Clinical Pathology, 2000
- Evidence that “myofibroblast-like” cells are the cellular source of capsular collage in hepatocellular carcinomaJournal of Hepatology, 1997
- Chemotactic factors, passive invasion and metastasis of cancer cellsImmunology Today, 1992
- Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesNature, 1985