Helicobacter pylori infection stimulates intestinalization of endocrine cells in glandular stomach of Mongolian gerbils
- 1 October 2006
- journal article
- Published by Wiley in Cancer Science
- Vol. 97 (10), 1015-1022
- https://doi.org/10.1111/j.1349-7006.2006.00273.x
Abstract
Intestinal metaplasia has been investigated extensively as a possible premalignant condition for stomach cancer but its pathogenesis is still not fully understood. In the present study, we examined the relationship between endocrine and mucous cell marker expression periodically after Helicobacter pylori infection in the Mongolian gerbil model. The numbers of chromogranin A (CgA)-positive, gastrin-positive and gastric inhibitory polypeptide (GIP)-positive cells in H. pylori-infected groups was increased significantly compared with the non-infected case. However, CgA-positive and gastrin-positive cells then decreased from 50 through 100 experimental weeks after H. pylori infection, whereas GIP-positive cells increased. Coexistence of gastrin-positive and GIP-positive cells was detected in the same gastric and intestinal mixed phenotypic glandular-type glands. In conclusion, the endocrine cell phenotype is in line with that of the mucous counterpart in the glands of H. pylori-infected Mongolian gerbil stomach, supporting the concept that development of intestinal metaplasia is due to the abnormal differentiation of a stem cell.Keywords
This publication has 38 references indexed in Scilit:
- Role of Helicobacter pylori in Gastric Carcinogenesis: The Origin of Gastric Cancers and Heterotopic Proliferative Glands in Mongolian GerbilsHelicobacter, 2005
- Coexistence of gastric‐ and intestinal‐type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomachPathology International, 2005
- Earlier Helicobacter pylori Infection Increases the Risk for the N‐Methyl‐N‐nitrosourea‐induced Stomach Carcinogenesis in Mongolian GerbilsJapanese Journal of Cancer Research, 2002
- Long-term effects of Helicobacter pylori eradication in Mongolian gerbilsThe Esophagus, 2002
- Reversibility of Heterotopic Proliferative Glands in Glandular Stomach ofHelicobacter pylori-infected Mongolian Gerbils on EradicationJapanese Journal of Cancer Research, 2002
- Hexosaminidase‐altered Aberrant Crypts, Carrying Decreased Hexosaminidase α and β Subunit mRNAs, in Colon of 1,2‐Dimethylhydrazine‐treated RatsJapanese Journal of Cancer Research, 2001
- Long-term Helicobacter pylori colonization produces G cell hyperplasia and carcinoid tumor in Mongolian gerbilsJournal of Cellular and Molecular Medicine, 2000
- Molecular Mechanisms of Enteroendocrine DifferentiatonAnnals of the New York Academy of Sciences, 1998
- Altered carbohydrate composition in colorectal adenomas and carcinomas: Histochemical characterization of N-acetylgalactosamine,l-fucose, and o-acetylated sialic acidThe Esophagus, 1996
- Endocrine cells in intestinal metaplasia of the stomachThe Journal of Pathology, 1984